KUMJ | VOL. 14 | NO. 2 | ISSUE 54 | APR-JUN. 2016
Role of C-reactive Protein in Acute AppendicitisAbstract:
Ghimire R, Sharma A, Bohara S
Acute appendicitis is the common surgical emergency. This study analyzed the value
of C-reactive protein as the diagnostic marker of acute appendicitis.
To assess the level of C-reactive protein in acute appendicitis and to relate the
quantitative measurement with degree of inflammation of appendix.
A cross sectional study was done with consecutive patients diagnosed with acute
appendicitis that underwent appendectomy over six months period. Peroperative
findings and histopathology report were compared and analyzed with the level of
A total of 54 patients were enrolled in this study. 94.40% were proved as acute
appendicitis in histopathology. The level of C-reactive protein was significantly raised
among highly inflamed appendix. C-reactive protein showed 84.31% sensitivity,
66.66% specificity, 97.72% positive predictive value and 20% negative predictive
value in diagnosing acute appendicitis.
With degree of inflammation of appendix, value of C-reactive protein was raised.
Quantitative assessment can predict severity of inflammation. Raised level of
C-reactive protein is an aid for diagnosing acute appendicitis.Keyword :
Acute appendicitis, C-reactive protein, Histopathology.