KUMJ | VOL. 15 | NO. 1 | ISSUE 57 | JAN.-MARCH, 2017

Gene-environment Interaction: The Causes of High Obesity Incidence
Mohammed S. Ellulu, Marwan O. Jalambo

Urbanization has provided experimental settings for testing the interactive relationship between genetic background and changes in lifestyle and dietary patterns. The concept of gene-environment interaction was described by epidemic of obesity along with urbanization. Genome-wide association has identified several genes such as melanocortin-4 receptor that associates with environmental influences of obesity. Gene environment (GxE) interaction refers to modification by an environmental factor of the effect of a genetic variant on a phenotypic trait. GxE interactions can serve to modulate the adverse effects of a risk allele, or can exacerbate the genotype-phenotype relationship and increase risk.
Keyword : Environmental factors, gene-environment interaction, genetic predisposition, obesity, social networks