KUMJ | VOL. 11 | NO. 4 | ISSUE 44 | OCT-DEC, 2013
Clinical Profile and Antibiotics Sensitivity in Childhood Urinary Tract Infection at Dhulikhel Hospital
Singh SD, Madhup SK
Abstract: Background
Urinary Tract Infection implies presence of actively multiplying organisms in the
urinary tract. Although it is infrequently associated with mortality, it is still a
significant cause of morbidity. Early diagnosis is critical to preserve renal function
of growing kidney.
Objective
Our purpose was to determine the clinical, microbiologic profile and antibiotic
sensitivity of such infections in pediatric Urinary Tract Infection (UTI) patients at
Dhulikhel Hospital.
Methods
A hospital based prospective descriptive study of 135 children from 2 months to
16 years, with clinical diagnosis of urinary tract infection who visited the pediatric
department of Dhulikhel Hospital over the period of 15 months were enrolled in
the study. All patients underwent routine urine analysis and culture. Children with
recurrent UTI underwent micturating cystourethrogram (MCUG). Children with
recurrent UTI of more than two years and with feature of pyelonephritis underwent
USG abdomen as well. Complications and response of the treatment was observed
in all cases of UTI. All data were entered in Epidata and data analysis was done using
spss 16 version.
Results
Among 135 children, 32.5% were male and 67.4% were female. Fever was the most
common presenting symptom in 74.80% of patients followed by dysuria in 54.1%.
Among these children 95.6% had significant pyuria and 45% had culture positive
infection. Children who showed positive for bacteriuria, Escherichia coli (78.7%)
was the most common organism and are more than 80% sensitive to Amikacin,
Gentamicin, Ceftriaxone, Ofloxacin, Nalidixic acid, Imipenem and Vancomycin.
Co-trimoxazole was the most common drug used for treatment with a mean drug
respond time of (meanħS.D) of 2.21ħ.78 days. 2ħħ. Children who had recurrent UTI
were more prone to develop culture positive UTI (p=0.0001).
Conclusion
Urinary Tract Infection in female was almost twice more common than in male. Cotrimoxazole
was the most common drug used for treatment, sensitivity of this drug
was less than 50% for all organisms.
Keyword : Bacteriuria, pyuria
