KUMJ | VOL. 10 | NO. 3 | ISSUE 39 | JUL-SEP, 2012
Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal
Yadav NK, Thanpari C, Shrewastwa MK, Mittal RK
Abstract: Background
Type-2 diabetes mellitus is an independent risk factor for coronary artery disease
and risk of coronary disease is three to four fold increased in patients with diabetes
compared with non-diabetic population and 60-80% 0f type-2 diabetics are obese.
Methods
This study was conducted in Nepalgunj Teaching Hospital, Kohalpur, Banke, Nepal,
between 1st March, 2011 and 28th February, 2012. A total of 150 samples were
taken to assess the lipid profile in type-2 diabetic patients associated with obesity
and 25 obese controls for their lipid profile. Venous blood samples were taken from
all the subjects in the morning after fasting overnight. Exclusion criteria included
pregnancy, chronic infectious disease, heart failure; renal failure and drug allergy
were confirmed from the subject’s personal physician report and a detailed history.
The data was analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social
Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI
Info 3.5.1 Windows Version.
Results
The mean ± SD age of diabetic patients with obesity was 53.76 ± 6.23 while the
mean ± SD age of control was 49.61 ± 4.8. Out of 150 patients 105 (70%) were
males and 45 (30%) were females. Among control subjects 16 (64%) were males
and 9 (36%) were females. Obese type-2 diabetic patients when compared to obese
control subjects showed statistically significant increase in the levels of serum total
cholesterol (p ˂ 0.001), serum triglycerides (p ˂ 0.001), serum LDL-cholesterol (p
˂ 0.001) while serum HDL-cholesterol levels did not show statistically significant
difference in the two group (p ˃ 0.05).
Conclusion
This study showed obese diabetic individuals have dyslipidemia and more prone to
develop cardiovascular diseases.
Keyword : Lipid profile, Type-2 diabetes mellitus, Obesity
