Objective: The present study was undertaken to compare the haemodynamic responses with pethidine vs.

Butorphanol intraoperatively in open cholecystectomy cases in KMCTH.

Method: In this randomized study, all together 40 patients undergoing routine cholecystectomy surgery were included. Group A received Pethidine 1mg/kg and Group B received Butorphanol 0.04mg/kg intraoperatively. Heart rate and blood pressure were recorded before injection of the drug, after injection, before intubation, after intubation, before skin incision, after incision, before extubation and after extubation Data analysis was done using independentsample “t” test.

Result: Our study showed no statistical significance in haemodynamic responses with either pethidine or

Butorphanol in open cholecystectomy cases.

Conclusion: Both drugs appear equally good analgesics in our study.