Aim and Objective: The main objective was to study the different types of regimen of prophylactic antibiotic in different surgeries in hospitals of western region, particularly, Pokhara valley and the hospitals were Western Regional Hospital (WRH) and Manipal Teaching Hospital (MTH).

Methodology: A descriptive, quantitative, retrospective study were used to evaluate the patients’ undergone surgery in the year 2059 BS (15th April 2002 – 14th April 2003). The total of 950 patients, 450 from WRH and 500 from MTH were taken from the medical record for the study. Data about different types of prophylactic antibiotic regimen was collected.

Conclusion: The most common surgery in MTH is dilatation and curettage (D and C) and in WRH is caesarean section (CS). In both hospitals Ampicillin+Cloxacillin was the most commonly used regimen, 12.4% in WRH and 34% in MTH. In WRH ciprofloxacin and cefotaxime was also used by 12.4%. Ciprofloxacin and gentamicin (12%) combination was the third commonly used regimen in WRH where as ciprofloxacin (28.4%), Ampi+Cloxa and gentamicin (22.4%) in MTH.