KUMJ | VOL. 15 | NO. 4 | ISSUE 60 | OCT.-DEC. 2017
Efficacy of Salbutamol in Mixed Obstructive and Restrictive Pattern Spirometry
Tuladhar LR, Tamrakar (Tuladhar) ET
Abstract: Background
Salbutamol is a short acting β
agonist bronchodilator most commonly used for
management of asthma and chronic obstructive pulmonary disease. Besides the
disease state, it is also used for bronchodilator reversibility in spirometry. The
spirometry reading show one of the four patterns i.e. normal, obstructive, restrictive
and combined or mixed (obstructive-restrictive).
Objective
2
To determine the efficacy of salbutamol in mixed obstructive and restrictive pattern
spirometry.
Method
A descriptive cross sectional study was conducted at Nepal Medical College and
Teaching Hospital (NMCTH) for a period of 9 months. A total of 70 patients who
presented with symptoms of respiratory disease in medicine outpatient department
(OPD) in which spirometry was performed were selected. Of the 70 patients, 35 with
mixed pattern spirometry were selected as cases and remaining 35 with normal
spirometry were selected as control. After taking informed consent, spirometry
parameter were measured before and after salbutamol therapy. Data was collected
from medicine department, pulmonary function test (PFT) unit. All the data were
entered in statistical package for social sciences (SPSS version 20) and Forced
expiratory volume in first second (FEV
1
), Forced vital capacity (FVC), FEV
/FVC and
Peak expiratory flow rate (PEFR) were analyzed.
Result
There was significant difference (p<0.05) in spirometry parameters (i.e. FEV
, FVC,
PEFR) when after salbutamol therapy was compared from before therapy. Statistical
significance was also seen in percentage change in spirometry parameter (i.e. %FEV
change, %FVC change, % change in ratio of FEV
/FVC and %PEFR change) between
case and control groups.
1
Conclusion
Salbutamol is an effective bronchodilator in mixed pattern or combined obstructive-
restrictive lung disease.
Keyword : Bronchodilation, Mixed obstructive and restrictive lung pattern, Salbutamol, spirometry
