KUMJ | VOL. 19 | NO. 2 | ISSUE 74 | APRIL-JUNE 2021
Does the Preoperative Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio Associate with Clinic-pathological Characteristics in Papillary Carcinoma of Thyroid
Shrestha BL, KC AK, Rajbhandari P, Dhakal A, Shrestha KS
Abstract: Background
Thyroid cancer is associated with local and systemic inflammatory activities. Many
systemic inflammatory markers including the neutrophil-to-lymphocyte ratio
(NLR) and platelet-to-lymphocyte ratio (PLR) had shown credible and independent
prognostic biomarkers in different malignant conditions. These markers are easy to
reproduce, measure and inexpensive also. So, the preoperative evaluation of NLR
and PLR is helpful in evaluating tumor growth and prognosis of papillary carcinoma
of thyroid.
Objective
To evaluate the association of pre-operative NLR and PLR with clinic-pathological
characteristic in papillary carcinoma of thyroid.
Method
This was a retrospective study performed in thirty one patients with the diagnosis
of papillary carcinoma of thyroid. Preoperative NLR and PLR values were correlated
with the clinical parameters like age, gender, lymph node metastasis, tumor size and
pathological features (e.g., multifocality, bilaterality, extrathyroidal spread).
Result
There were thirty one patients, amongst which 13 were male and 18 were female.
Similarly, the age distribution ranges from 27-68 years. The value of NLR was
2.37±1.09, and the value of PLR was 96.69±49.53.The increase in NLR was associated
with increase in tumor size with statistically significant results. Similarly, increase in
PLR was associated with increase in tumor size and multifocality with statistically
significant results.
Conclusion
Increase NLR and PLR is associated with lymph node metastasis, extra thyroidal
extension, multifocality of tumor and also bilaterality, so the risk can be stratified
beforehand with measurement of NLR and PLR.
Keyword : Lymph node metastasis, Neutrophil-to-lymphocyte ratio, Papillary carcinoma of thyroid, Platelet-to-lymphocyte ratio
