KUMJ | VOL. 20 | NO. 1 | ISSUE 77 | JANUARY - MARCH, 2022
Visual Evoked Potentials (VEPs) in Patients with Type 2 Diabetes Mellitus
Subedi P, Limbu N, Maskey R, Baral DD
Abstract: Background
Type 2 diabetes constitutes about 85-95% of all diabetes in developed countries, and
accounts for an even higher percentage in developing countries. Diabetic retinopathy
is probable the most characteristic, easily identifiable and treatable complication of
diabetes, but remains an important cause of visual loss.
Objective
To study P100 latencies and inter ocular latency difference in diabetic group and
compared it with a control group and study the correlation between P100 and inter
ocular latency difference with the duration of disease in diabetic group.
Method
A comparative, cross sectional study was done from September 2016 to January
2018 in Neurophysiology Lab, Basic and Clinical Physiology, BP Koirala Institute
of Health Sciences. The sample size was 64 and random sampling technique was
used. Subjects were divided into three groups according to the duration of disease.
Anthropometric and visual evoked potentials were recorded. Descriptive analysis,
analysis of covariance and Post Hoc multiple comparison analyses were done using
SPSS 11.5. Pearson’s correlation was applied between P100 latency and inter ocular
latency difference with the duration of disease.
Result
On using analysis of covariance, P100 latencies were significantly prolonged in
diabetic as compared to healthy controls (p < 0.001). Post Hoc multiple comparison
showed significant differences in both left and right P100 latencies within diabetic
groups and between diabetic groups and healthy controls. Left inter ocular latency
difference showed positive correlation with the duration of disease.
Conclusion
P100 latencies are significantly prolonged in diabetes patients and is positively
correlated with duration of disease. Visual evoked potential test can be useful for
detecting retinal dysfunction before the appearance of symptoms of retinopathy.
Keyword : P100 latencies, Type 2 diabetes, Visual evoked potentials
