KUMJ | VOL. 20 | NO. 2 | ISSUE 78 | APRIL - JUNE 2022
Correlation between Sonoelastography and Histopathological Findings in Evaluation of Chronic Renal Allograft Disease
Bhandari RM, Suwal S, Chataut D, Ansari MA
Abstract: Background
Non-invasive evaluation tool for allograft kidney is important to predict chronic
allograft dysfunction as it can be alternative to the invasive biopsy which is prone
to so many complications. Sonoelastography can assess the stiffness of the allograft
renal parenchyma, which is prone to undergo interstitial fibrosis.
Objective
To correlate sonoelastography with histopathology findings in the renal allografts.
Method
Sonoelastography was done in 60 renal allograft recipients prior to their biopsy
for various indications. Estimated glomerular filtration rate (eGFR) of the patient
were also obtained. Histopathology reports were collected to determine Banff
score of interstitial fibrosis. Descriptive measurements (Mean ± standard deviation,
Frequencies, Proportions) were calculated. Correlations among the variables were
measured using Pearson’s correlation, independent sample t-test, and ANOVA.
Result
The mean strain index (SI) was lower in higher grades of fibrosis. There was significant
difference in mean SI (F=18.264; df= 2,57; p < 0.001) among the histological grades
of fibrosis. Also a significant difference in SI among mild and moderate (S.E. 0.27, p
value < 0.001), mild and severe (S.E. 0.213, p value < 0.001) as well as moderate and
severe fibrosis (S.E. 0.244, p value < 0.001) was seen. Significant correlation of eGFR
with SI (p < 0.001) was also seen.
Conclusion
Strain index, measured with sonoelastography, significantly correlated with different
grades of tissue fibrosis. Thus it can be used as alternative method for evaluation of
renal allograft patients to avoid complications of biopsy.
Keyword : Allograft biopsy, Complications, Interstitial fibrosis, Renal allograft, Strain index
