KUMJ | VOL. 20 | NO. 3 | ISSUE 79 | JULY-SEPT. 2022
Prevalence of Suspected Cholangiocarcinoma Based on Ultrasonography Screening and its Associated Factors in Northeastern Thailand
Rayubkul J, Laohasiriwong W, Thinkhamrop B, Mahato RK, Khantikeo N, Pongpanich S
Abstract: Background
Ultrasonography of the liver allows detection of liver mass and bile duct
dilatation which are findings of suspected Cholangiocarcinoma so that early stage
Cholangiocarcinoma can be detected.
Objective
To estimate the prevalence of suspected Cholangiocarcinoma as well as its associated
factors.
Method
These reported results were obtained from the baseline screening for
Cholangiocarcinoma as of July 2013 of an ongoing project the Cholangiocarcinoma
Screening and Care Program conducted in Northeastern Thailand. Participants were
northeasterners who were at least one of the followings: 40 years or older, ever been
infected with liver fluke, ever been treated with praziquantel, or ever been consumed
raw fresh water fish. Ultrasonography was done by well-trained medical radiologists.
Result
Of the total 1,196,685 participants, 58.9% were females with a mean age of 58.2
(standard deviation ± 9.9) years. Suspected Cholangiocarcinoma was found in 15,186
(2.6%; 95% CI: 2.56 to 2.65) individuals. The results observed that the participants
with higher age group had high association as compared to younger age group
(AOR=1.98; 95% CI: 1.77 to 2.21; p-value < 0.001), hepatitis B infected participants
were highly significant as compared to the non- hepatitis B infected (AOR=1.22;
95% CI: 1.07 to 1.39; p-value = 0.002) and participants having Hepatitis C were also
significantly associated with Cholangiocarcinoma infection (AOR=1.46; 95% CI: 1.04
to 2.05; p-value = 0.029) based on ultra-sonographic screening respectively. However,
patients having diabetes were less likely to be associated with Cholangiocarcinoma
(AOR=0.87; 95% CI: 0.81 to 0.93; p-value < 0.001).
Conclusion
About one out of a hundred cases required further investigations such as Magnetic
resonance imaging or Computed Tomography. Early age of ultrasonography
screening for Cholangiocarcinoma enhanced the opportunities for early detection of
Cholangiocarcinoma and might reduce irrational requests for expensive or invasive
methods of diagnosis.
Keyword : Cholangiocarcinoma, Suspected case, Ultrasonography screening
