KUMJ | VOL. 21 | NO. 1 | ISSUE 81 | JANUARY - MARCH, 2023
Globozoospermia
Bhattarai L, Gautam B, Raut BB, Chettri S
Abstract: Male infertility may be due to low sperm concentration, poor sperm motility, or
abnormal morphology. Among the factors involved in male infertility, there is a
rare morphology disorder called “Globozoospermia”. This condition is primarily
characterized by the presence of round-headed spermatozoa, absence of acrosomal
cap and cytoskeleton defects around the nucleus. The morphological characteristics
of globozoospermia are formed during spermiogenesis. We report here a case of
male infertility due to morphological disorder Globozoospermia. Assessment of
semen by observing macroscopic and microscopic parameters are not sufficient
for sperm analysis. In present case, macroscopic and microscopic assessment was
within normal range. Morphological assessment showed 80% of spermatozoa
with round head and absence of acrosomal cap. The absence of acrosome makes
fertilization impossible since these sperm are unable to bind to the zona pellucida.
By using Intracytoplasmic Sperm Injection (ICSI), conception is possible; however,
the fertilization rate remains very low.
Keyword : Globozoospermia, Male infertility, Morphology
