KUMJ | VOL. 21 | NO. 3 | ISSUE 83 | JULY-SEPTEMBER. 2023
Thyroid Hormone Abnormalities and Associated Risk Factors among Acute Coronary Syndrome Patients at a Tertiary Care Hospital
Shreewastav RK, Dhungana SP, Pokhrel S, Jayshwal R, Pandey H
Abstract: Background
Thyroid dysfunction and associated factors like age, sex, diabetes mellitus,
hypertension, smoking, family history of coronary artery disease and dyslipidemia
contributes the risk for acute coronary syndrome.
Objective
To find out the prevalence of thyroid dysfunction and associated risk factors among
acute coronary syndrome patients at this tertiary care hospital in eastern Nepal.
Method
A descriptive cross-sectional study was carried out prospectively among acute
coronary syndrome patients at a tertiary care Hospital. Diagnosis of acute coronary
syndrome was made based on the medical history, Electrocardiogram abnormalities,
and cardiac markers. Thyroid function test and estimation of other blood parameters
were done in the blood of the patients. Other relevant information and medical
history of the patients were collected by using proforma.
Result
Out of 186 total acute coronary syndrome patients, 127 (68.28%) were male and
mean age of all patients was 60.0 ± 13.7 years. Thyroid dysfunction was observed in
52 (27.95%) patients, out of that subclinical hypothyroidism was mostly seen in 30
(16.12%) patients followed by hypothyroidism in 13 (6.98%). The number of patients
with hyperthyroidism and subclinical hyperthyroidism was 6 (3.23%) and 3 (1.62%)
respectively. Associated factors like hypertension, diabetes mellitus, smoking, family
history of coronary artery disease and dyslipidemia was observed in 80 (43.01%), 42
(22.58%), 83 (44.62%), 11 (5.91%) and 79 (42.47%) patients.
Conclusion
Acute coronary syndrome was predominantly seen in male and subclinical
hypothyroidism was a major thyroid dysfunction observed among the patients.
Hypertension, dyslipidemia, diabetes mellitus and smoking was found to be
associated in a proportion of patients with acute coronary syndrome.
Keyword : Acute coronary syndrome, Diabetes mellitus, Hypertension, Risk factors, Thyroid function test
