The oral cavity is a major site of chronic infection and inflammation, particularly periodontal or chronic gum

diseases. In recent years there has been increasing interest in the “periodontal systemic connection” between

periodontal health parameters and risks of cardiovascular disease. Given that poor oral health and cardiovascular disease are major worldwide health problems, their association are potentially important. The article summarizes the evidences from epidemiologic studies and studies that focused on potential contributing mechanisms to provide an insight of this association