Background:Meningitis is a serious infection. Little is known about the bacterial agents and their

antibacterial sensitivity in Nepalese children.

Objectives:To study bacteriological agents, clinical profile and immediate outcome in patients

admitted to children’s ward of Patan Hospital with meningitis.

Methods:Prospective observational study conducted in paediatric ward of Patan Hospital. All

the children admitted to the ward, with the diagnosis of culture proven bacterial

meningitis’ on discharge were eligible.

Results:Out of 7,751 children, 296 (3.8%) had meningitis. This was a group ranging from

neonates to adolescents aged 18 years. Only 13 (4.4%) of cerebrospinal fluid

samples taken from them yielded positive culture reports. The organisms were pneumococcus (6), Haemophilus influenza ‘b’ (3), â-hemolytic Streptococcus (1), á-hemolytic Streptococcus (1), N. meningitides (1) and Pseudomonas (1). Whereas Haemophilus influenza ‘b’ was isolated from young infants, pneumococci were found in the young as well as the old. Fever, vomiting, high leukocyte count with left shift were all commonly present. All but one had cerebrospinal fluid pleocytosis. Low sugar and high protein was found in most specimens. Neuroimaging was done in six children of which three were abnormal (all young infants and pneumococci cases). Ceftriaxone was given to all but one child. Everybody recovered but three had complications – profound hearing loss and cortical atrophy with subdural collection in pneumococcal and septic arthritis with persistence of fever in

Haemophilus influenzae ‘b’ meningitis.